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KMID : 1103720160740010015
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Journal of the Korean Society of Radiology
2016 Volume.74 No. 1 p.15 ~ p.21
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Recurrent and Second Breast Cancer Detected on Follow-Up Mammography and Breast Ultrasound after Breast-Conserving Surgery: Imaging Findings and Clinicopathologic Factors
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Yoon Ga-Young
Cha Joo-Hee
Kim Hak-Hee
Shin Hee-Jung
Chae Eun-Young
Choi Woo-Jung
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Abstract
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Purpose
To assess the imaging and clinicopathologic outcomes of recurrent and second breast cancer after breast-conserving surgery for invasive ductal carcinomas detected on follow-up mammography and breast ultrasound (US).
Materials and Methods
Seventy-six women with an ipsilateral breast tumor recurrence (IBTR) or regional lymph node recurrence and/or contralateral breast cancer (RLNR & CBC) after breast-conserving surgery were included in this study. The mammography and US images were analyzed and the clinicopathologic parameters were compared between the groups.
Results
Thirty had an IBTR, and 46 had a RLNR & CBC. The IBTR group's mammography and US images frequently revealed calcification and masses on the breast, respectively. The most frequent site of RLNR detected during follow-up mammography and breast US was the axilla. In univariate analysis, the tumors in the IBTR group were predominantly estrogen receptor (ER)-negative, HER-2 overexpression, and p53-positive. ER and HER-2 were shown by the multivariate analysis to be independent parameters associated for both types of recurrences.
Conclusion
A mass or calcification is frequently present in IBTR and the axillary lymph node is the most frequent site of RLNR. ER and HER-2 status are major independent factors associated with recurrent and second breast cancer.
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KEYWORD
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Breast Cancer, Recurrence, Mammography, Ultrasonography
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